The poisoning of fluoroquinolone is caused by antibiotics. It can result in serious side effects like nausea vomiting, diarrhea, depression, muscle pain and psychosis. Floxing is also a reference to this.
Patients who have suffered from side effects of an antibiotic that contains fluoroquinolone/quinolone must stay away from fluoroquinolones. Special consideration should be used in patients over the age of 65, those with kidney disease and people who have had an organ transplant.
Most quinolone antibiotics that are used are fluoroquinolones that contain a fluorine atom in their chemical structure . They are effective against Gram-positive and Gram negative bacteria.
Fluoroquinolones “kill bacteria by blocking enzymes that typically untangle DNA during cell replication. Usually, these enzymes cut DNA’s double helix, then pass another section of the length of the strand through the gap and then fix the cut.
Quinolones have the ability to bind to enzymes, thereby preventing the enzymes from fixing their cuts. In the 80s, scientists added fluorine atoms to structure of the quinolones. This enabled antibiotics to enter tissues throughout the body, including the central nervous system. Also, it improved their efficacy against a range of bacterial infections.
Fluoroquinolones may be beneficial in certain conditions, including life-threatening, in cases where other antibiotics are not sufficient efficient.
However, they, along with numerous antibiotics, are frequently used. A number of FDA warnings have been issued to restrict the usage of fluoroquinolones. They have been associated with severe side effects. A variety of label modifications have been mandated , and certain fluoroquinolones have warnings in the form of a black box.
What antibiotics are fluoroquinolones and which are not?
These medications comprise Cipro gemifloxacin [Factive], ciprofloxacin [Cipro], levofloxacin (“Levaquin”), levofloxacin (“Levaquin”) as well as moxifloxacin (“Avelox”), norfloxacin („Noroxin”), and ofloxacin (“Floxin”Floxin”).
What is fluoroquinolone-related toxicity syndrome?
Signs + Symptoms
Fluoroquinolone drugs are associated with possibly serious, long-term permanent side effects, which include toxicities to the central nervous system, cardiovascular system, and the musculoskeletal system. Other Cipro toxicity symptoms include:
– Damage to DNA and mitochondrial dysfunction
– Brain Fog
– Peripheral Neuropathy
– Blurry Vision
– DNA Damage
– Depression/anxiety as a result of Gaba of Gaba and Gaba and Gut Damage
– Tendonitis
– Muscle Atrophy
– Increased reflexes
Tendonitis, low back pain and tendon ruptures are the first signs of Ciprotoxicity. Fluoroquinolones may increase the risk of peripheral neuropathy by 47% over time.
Ciprofloxacin is shown to inhibit normal maintenance and transcription of mitochondrial DNA, by altering mtDNA topology. Tenocytes can be damaged by mitochondrial DNA during fluoroquinolone treatment may be involved in tendinitis and rupture of the tendon. It can also cause inflammation and fatigue.
For more information, click fluoroquinolone toxicity treatment
